Uncovering IGF1R-Mediated Transcytosis: Distinct Endocytic Pathways Enable Robust BBB Transport in APOE4 Genotype Populations

• Exploring the differentiation point of Grabody-B targeting IGF1R vs conventional TFR1-based shuttles in APOE4 populations
• Deciphering the multiple transcytosis pathways used by IGF1R-based shuttles using mechanistic animal studies
• Demonstrating how IGF1R-targeting shuttles uniquely utilize filamentous actin

Speakers:

Sungwon An

Head of Neuroscience

ABL Bio Inc.