Jae-young Koh
Chief Scientific Officer Zincure
Seminars
Wednesday 9th December 2026
Restoring Lysosomal Function to Enable TDP‑43 Clearance: ZCS1 as a Disease-Modifying Strategy in ALS
4:30 pm
- Deciphering how ZCS1 promotes reactivation of lysosome enzymatic function via TFEB regulation
- Demonstrating TDP-43 clearance and NfL reduction in (SOD1)-G93A mouse models
- Future directions for progressing towards GLP toxicology studies and first-in-human trials in 2027
