Restoring Lysosomal Function to Enable TDP‑43 Clearance: ZCS1 as a Disease-Modifying Strategy in ALS

• Deciphering how ZCS1 promotes reactivation of lysosome enzymatic function via TFEB regulation
• Demonstrating TDP-43 clearance and NfL reduction in (SOD1)-G93A mouse models
• Future directions for progressing towards GLP toxicology studies and first-in-human trials in 2027

Speakers:

Jae-young Koh

Chief Scientific Officer

Zincure